Analysis of Nestles Position in India

Analysis of Nestles Position in India Nestle is one of the largest companies in the world. It produces different types of products and was based in different parts of the world. It was started in 1868 by Henri Nestle, who set up a sales office in London. The company went under the new ownership when Henri Nestle retired in 1875.Nestle opened its first factory in 1901 in UK and got merged with the Anglo-Swiss milk company which was founded by Charles and George page. It has acquired its own brand image over the years by innovating new products and attracting people all over the world with its quality products. Nestle became one of the leading companies in the world when it started producing chocolates. The chocolate production began at Hayes in 1913 and the famous white chocolate Milky Bar was released into the market in 1937. The other products of Nestle are coffee, milk, chocolates etc. The company has its branches in 86 countries like India, Pakistan, US, South Africa, brazil, Sri Lanka, France , Middle east countries etc all over the world and nearly employs 283,000 people. It has over 250,000 shareholders, while most of them are from Swiss. Nestle products are well known in the whole word for their wide range of products which include coffee , infant nutrition, baby products ,chocolates , milk products etc. Nestle products are cheaper when compared to other milk products and chocolates and the reputation in the market is good which makes the company to release wide range of products in the market across the whole world. Nestle is the world leader in the categories of coffee, infant nutrition, chocolates etc. The company respects the opinions of its customers and makes sure that the products are manufactured according to their interests. FIVE COMPONENTS OF ARMSTRONGS MODEL: BASIS: the environmental factors that are to be taken into account as the essential background for the organisations HR strategies. These factors can be analysed by using SWOT or PESTLE analysis. CONTENT: the details of the proposed HR strategies of an organisation must be included RATIONALE: the business case for the strategy. IMPLEMENTATION: finding the ways and plans to implement the proposed HR strategies. COST AND BENEFIT ANALYSIS: analysing the benefits and costs of implementing a strategy and acting according to the outcomes that may occur. NESTLE follows the strategies like commitment strategy, developing trust, culture management etc. By following and implementing these type of strategies, NESTLE has innovated and developed itself throughout the years. Let us evaluate the HR strategy of NESTLE organisation using Michael Armstrongs model for the strategys design. BASIS: the environmental factors of the NESTLE organisation are evaluated using the SWOT analysis. STRENGTHS: The company has a great support from its parent company which has a great influence all over the world. It has huge brand strength all over the world. The brands like NESCAFE, MAGGI and CERELAC which are generic to their product categories are very strong in the Indian market. Around 67% of the population use Nescafe, Maggi and Cerelac for their daily uses. Another main Strength of the company is, it continuously introduces new products in to the market with innovative thoughts and attracts people towards it. It makes sure that its products are manufactured with quality. There are nearly 3500 scientists in the companys RD department to innovate new thoughts and ideas. It is a truly global company which is operated in 77 countries. The competition from other organisations doesnt affect Nestle because of the low cost and high quality it maintains. It has a very strong work force unlike the other organisations. WEAKNESS: Because of the uneven nature of the Indian market, the things get more complicated. It is very much important to maintain good hygiene standards, talented personnel in the food industries like Nescafe. It is very difficult to maintain these standards in the big countries like India which has a complex supply chain management. OPPURTUNITIES: There are lots of opportunities to the company in the huge country like India. There are lots of towns in India where the products of Nescafe are not available. It can extend to those towns and villages and can increase its market. The company can extend its product folio by introducing new products into the market. As India is a huge country with lots of resources and manpower, it can be made as the export hub to achieve better results. Everyone is becoming a health freak now days, including the United States. So, health based products are having great opportunities in the global market. THREATS: The main threat for any organisation is its competitor. There is a huge competition among the organisations. Nestle faces huge competition from the organised and unorganised sectors. Moreover, the Indian government has decreased the import duty of food products, making the things worst. The organisation does not have any threats from the small scale industries but it will have threats from the organisations which are established with large investments and big brand value. The performance of FMCG sector is very less in the past 2-3 years, even though there is a decent pace of growth in the economy of the organisation. Some of the markets in which the company is about to enter, are already mature regarding these products. CONTENT: The main principle of HR strategies of the NESTLE organisation is its products growth through innovation and renovation. The other important strategies are Attracting dynamic employees and giving training to them Developing the management Respecting other cultures and traditions Providing training to the new comers Some other principles of proposed HR strategies are maintaining diversity in the manufacturing of products, despite of introducing several products in to the organisation. RATIONALE: Let us have a look on the business case of proposed HR strategies of NESTLE organisation. NESTLE has its Kit Kat manufacturing plant in York England. Ian Jobson is the manger of that plant. For manufacturing a ton of Kit Kat chocolate, it used to take like 38 man hours. It is a waste of time and man power and even it costs a lot of money to the organisation. To overcome this problem, they have implemented new strategies in the manufacturing of the chocolate. They have innovated and renovated their strategies and came up with a new strategy. They have decreased the human labour and introduced robotics to make the work easier. They used robotics, automated packaging, and production line improvements and they have reduced the manufacturing time to 23 hours. IMPLEMENTATION: NESTLE makes sure that the proposed strategies are implemented without any failure. It provides the necessary resources and necessary funds to the HR department to implement their strategies. It follows different strategies and concepts to reach the better heights and to sustain in this competitive world. It has a research development department, who works on innovation of the new products and renovating the available products of the company. It opens new branches every year to attain a greater grip on the market. It commits to a strong work to achieve better results NESTLE makes sure that it follows all the local laws and legislations, as reputation of the company affects the sales of the organisation It gives rights to the employees to question their superiors about an unfair evaluation It motivates its employees, train them in maintaining teamwork, cooperate and integrate with the organisations strategies. COST AND BENEFIT ANALYSIS: NESTLE tries to decrease the extreme utilization of natural resources. By doing this, it benefits in increasing the human resources, expands contact to the financial resources. The managers and the individual employees are very benefited by the HR strategies of NESTLE. The company believes in the individual achievement of the employees plays a major role in the development of an organisation. To encourage its employees, the HR department has designed a pay structure to its employees. The company even introduced practices like job enlargement to encourage their employees and to break the limitations of their work. Let us evaluate the pay structure of the NESTLE organisation: NESTLE suggests reasonable remunerations to the employees. The level of remuneration is maintained above the average in the industry. The unpredictable part of salary is relatively big in rewarding an individual performance. The variable part of salary for higher management is based on the performances and achievements of the individuals and their team. BENEFITS: The employees can apply up to particular number leaves either personal or medical. They can have the assistance scheme for their childrens education. The organisation offers provident fund to their employees. The other benefits for the employees include retirement gratuity scheme, conveyance repayments, insurance for accidents etc. The other concepts that can be included are providing recruitment services, talent management and international HR etc. The recruitment services of NESTLE are very much recognised all over the world for their methods of recruitment. They dont just try to fill the jobs but makes sure that the right person is selected for the right job. They select the people who are dynamic, hard working, flexible and honest. Those candidates are selected whose values are similar to the companys culture. The HR officials are the one who takes the final decision in selecting a person. The company even maintains a Rewards and Employee relations team, which provides guide lines to the employees in necessary situations. They provide guidance to the line managers, HR managers, research and development department etc. It provides a health environment to its employees. In a multi-national company like NESTLE, the employee turnover is less than 5%. EMPLOYEE RELATIONS: Nestle gives importance to the personal life of their employees. So, it makes sure that the work life and personal life of their employees is balanced. It maintains a separate policy in which work/life balance is given importance. REWARDS AND INCENTIVES: Nestle encourages its employees by giving rewards and incentives. By doing this, the employees who are eager to win awards will work hard for the development of the organisation. Competitiveness among the employees will result in the growth of the organisation. So, the organisation even offers a competitive reward package to its employees. The company awards NESTLE idea award every quarter to the employees who come up with innovative ideas. These are the different concepts and theories of NESTLE. CONCLUSION: Michael Armstrong gave a brief explanation on the components that are to be included in the Human Resource strategies of an organisation. He covered all the important aspects which play a major role in the development of an organisation. By evaluating the HR strategy of NESTLE using Michael Armstrongs strategy model, we can understand that NESTLE is very keen and careful regarding the strategies it had implemented and it is going to implement in the future. NESTLE concentrated on its strengths, its weaknesses, the opportunities it has and the threats it has to face and planned strategies to face these problems. By the Michael Armstrong five components model the HR strategies are evaluated. In the first component basis for the organisation, HR strategies are estimated using SWOT analysis and the strengths and weaknesses are evaluated and future opportunities and threats are analysed. In the second component content the innovation and renovation of the Nestle organisation are discussed where the strategies state the need for development in the management and opportunities for the skilled employees. In the third component, Rationale shows the reduced man power to increase productivity by using robotics as a strategy which gave good results by decreasing man power to 23 hours from 38 hours. In the fourth component implementation stated that the need for urgency for the development of organisation by increasing the branches of nestle every year. In the fifth component cost and benefit analysis states the remuneration of the employees it depends on the individual performance which reflects the NESTLE organisations growth.

The Collar :: essays papers

The Collar George Herbert was born on April 3, 1593 at Montgomery Castle, the fifth son of an eminent Welsh family. Herbert's religious beliefs caused him to be an active opponent of the puritans and the Calvinists. Herbert became the cannon of Lincoln Cathedral and in 1630 he took holy orders. During the years Herbert spent at Bemerton he worked on a collection of verses known as The Temple. Upon his death they published the manuscript. The poem "The Collar" is a complaint voiced by person embittered against the constraints that bind him. Impatient with the human condition, the writer resolves to break free. "My lines and life are free, free as the road, / Loose as the wind, as large as store" he insists. The accompanying gesture, "I struck the board and cried, 'No more!'" is a dramatic, and boastful act. The tone of these lines is recognized as an exaggeration. The writer is impatient with the need to recognize one's dependence and to accept one's need to worship and serve God. The poem as a whole is about blowing off steam. Herbert develops two quite vivid major images to build the poem's theme. The images of restraints such as "collars / cages / cable / rope"suggests something stiff and restrictive, but not harmful, like a noose or shackles. The title of the poem, "The Collar," an article of clothing a man wears when he must be at his best. The word "Collar" also refers to the white band worn by the clergy, and it is the role of priest the poem alludes to. This collar symbolizes the priest's role as servant. The writer chafes at being "in suit." The image has at least a double meaning. The word "suit" refers to the clerical "suit" and connotatively to the attendance required of a vassal at his lord's court. "Forsake thy cage, / Thy rope of sands." The word "cage" suggests a contraption for animals. The purpose is not to harm but merely to restrict movement, and keep from harm. This prevents the creature from getting hurt by its impulses and curiosity about what lies beyond the confines. This imagery of restraints suggests the writer of being in an animalistic state. This animalistic condition is clear when "as I raved and grew more fierce and wild/ At every word." The writer is getting himself worked up. He is unreasoning, like an animal. Even the text, seems to bark: "What? Shall I ever sigh and pine?

Carbon Dioxide In Beverages :: essays research papers

Carbon dioxide is a colorless gas, it has a small but sharp odor and a slightly sour taste. Each molecule of carbon dioxide consists of one atom of carbon and two atoms of oxygen. Its chemical formula is CO2. Carbon Dioxide is about 1.5 times heavier than air. The specific volume at atmospheric pressure (101.3 kilopascals) and 70 º F (21 º C) is 8.74 ft3/lb. Under normal conditions it remains stable, inert and non-toxic. To liquefy CO2 it must be under 300 pound per inch gage(psig) at 0 º F or 838 psig at 70 º F. Above the critical temperature of 87.9 º F, at which all three phases gas, liquid, or solid may exist in equilibrium with one another, CO2 can exist only as a gas, no matter what amount of pressure. When liquid CO2 is cooled to -69.9 º F and the pressure drops to 60.4 psig it turns into dry ice snow. All CO2 existing in the atmosphere is estimated to be 720 x 109. Carbon dioxide makes up about 0.03 percent of the air. Although that is a small amount, plants and animals depend upon it for life. Green plants make their nutrients with it. They mix the carbon dioxide with water to make sugar by a process called photosynthesis. From the sugar, the plants then make starch and cellulose. Animals eat the plants and in getting energy from the food, they produce carbon dioxide and return it to the air as they breathe. Research in Muana Loa and the South Pole showed that CO2 content in the atmosphere has increased from a presumed 250 ppm in the pre-industrial era to 315 ppm in 1958 and to 340 ppm in 1984. If this trend continues the CO2 concentration will reach about 600 ppm in the next century. Besides being produced by breathing, carbon dioxide is formed when carbon-containing materials such as wood, coal, and petroleum products are burned with plenty of oxygen in and around the fire. Carbon Dioxide has found many uses in the industrial world. CO2 is not usually taken from the atmosphere because the concentration is so low. The industrial worldâ₠¬â„¢s CO2 is commercial produced. The CO2 production plant, type CBU, is based on the combustion of oil or gas. The flue gas normally contains sulfur dioxide, which is removed by water and soda lye scrubbing. If combustion is based on sulfur free fuel the soda scrubber can be omitted.

Resources for Food Storage Warehouse Requirements

Warehouse Sanitation Workshop Handbook, by Education Resources Information Center (ERIC) – PDF http://www. eric. ed. gov/ERICWebPortal/search/detailmini. jsp? nfpb=true&_&ERICExtSearch_SearchValue_0=ED201821&ERICExtSearch_SearchType_0=no&accno=ED201821 Foreword (pg 31/67)| There is good description of the scope of how they define ‘Food Warehouse’ and differentiate it from Food Manufacturing| II Buildings and Grounds (pg 31 – 32)III Fixtures and Equipment (pg 32)| Can be used for Section 2: Warehouse exterior and surroundings| IV Sanitary Facilities (pg 32-33)V Sanitary Operations (pg 33-34)VI Procedures & Controls – Part I, J, K (pg 35 – 36)| Can be used for Section 8: Hygiene of premises including housekeeping, personal hygiene, pest control and waste disposal| VI Procedures & Controls – Part A to H (pg 34 – 35)| Can be used for Section 7: Safe Handling of Food| VII Personnel (pg 36)| Can be used for Sect ion 11: Appointment of hygiene officers and personnel training| Appendix (pg37-39)| Could be used as our Appendix and Checklist too| 2.Food Safety for Warehousing and Distribution (a training course that comes with a copy of the AIB International Consolidated Standards for Inspection: Food Distribution Centres) https://secure. aibonline. org/php/ecomm-catalog. php? catalogNbr=11-3375 3. Food Establishment Regulations, by Southern Nevada Health District – PDF http://www. southernnevadahealthdistrict. org/food-regulations/index. php Chapter 1 Purpose and DefinitionsChapter 9-1 Definitions| Can be used for Section 1: Definitions| Chapter 2 Management and Personnel Supervision| Can be used for Section 11: Appointment of hygiene officers and personnel training| Chapter 3-305. 11 Food Storage (pg 35/166)Chapter 3-305. 2 Food Storage prohibited areas (pg 36)| Can be used for Section 6: Safe storage conditions of food| Chapter 9-202 General Warehouses| Can be used for Section 3: Ware house structure, design and maintenance| Chapter 9-302 General Warehouses| Can be used for Section 7: Safe handling of food|Chapter 9-302. 17 to . 19| Can be used for Section 8: Hygiene of premises| Chapter 9-302. 20 Transportation| Can be used for Section 9: Transportation requirements| 4. Oregon ODA Food Safety Division http://oregon. gov/ODA/FSD/reg_law_index. shtml Division 25 – Food Establishment Standards and Standards for Retail Food Service Activities http://arcweb. sos. state. or. us/pages/rules/oars_600/oar_603/603_025. tml 603-025-0010 Definitions| Can be used for Section 1: Definitions Definition of Food Storage Warehouse: means any building or place where food is stored as a commercial venture or business, or stored in connection with or as a part of a commercial venture or business, but does not include a home, restaurant, rooming house, hotel or similar place where food is stored to be used or consumed by the owner or served to employees, customers, or guests, nor an establishment licensed by the department under other laws| 603-025-0020 General Standards (1) and (2)| Can be used for Section 2: Warehouse exterior and surroundings| 603-025-0020 General Standards (3) – (8)| Can be used for Section 3: Warehouse structure| 603-025-0020 General Standards (9) – (11)| Can be used for Section 8: Hygiene| 603-025-0020 General Standards (12)| Can be used for Section 11: Personnel| 603-025-0020 General Standards (13),(14),(16)| Can be used for Section 7: Safe handling| 603-025-0020 General Standards (15)| Can be used for Section 9: Transportation requirements| 603-025-0140 Food Storage WarehousesIn addition to the provisions of OAR 603-025-0020, a food storage warehouse shall comply with the following: (1) Cold Storage: Each cold storage room in a food storage warehouse shall be equipped with an accurate and easily visible thermometer with the sensing element at least five feet above the floor. (2) Morgue: The operator of a food storag e warehouse shall provide an area for the accumulation and holding of all damaged foods or foods which are or may be unwholesome. The operator shall maintain a program of timely and proper disposal of damaged or unwholesome foods to prevent development of insanitary conditions or vermin breeding places and rodent harborage.5. Organic Food Federation Storage, Warehouse & Transport Standards (PDF) http://www. orgfoodfed. com/Our%20Standards. htm 6. International Food Safety & Quality Network http://www. ifsqn. com/ http://www. ifsqn. om/brc-storage-and-distribution-quality-management-system-p-94. html 7. Wholesale Food Warehouse Risk Control Plan Workbook (PDF) sandiegohealth. org/food/wholesale_workbook. pdfSimilar Chapter III Food Storage Procedures| Can be used for Section 6: Safe storageCan be used for Section 7: Safe handling| Chapter IV Receiving, Transportation| Can be used for Section 9: Transportation requirements| Chapter V Food Security| Can be used for Section 11: Personnel| Chapter VI RecallChapter VII Traceback| Can be used for Section 13: Recall| Chapter X Pest Control| Can be used for Section 8: Hygiene| Sample Self-Inspection Form (pg 64/74)| Can be used as Appendix|

Business Management Motivation

Motivation is the willingness to exert high levels of effort toward organizational goals, conditioned by the effort's ability to satisfy some individual needs (Robbins, 168). For some business analysts, employee motivation is a good way to increase productivity in an organization. When people get motivated, they will have a reason to put more efforts on what they are doing. Motivation is a crucial management tool in lifting the organization's work force's ability. There are many different ways to motivate employees. Employers can motivate their workers as individuals, groups, teams, or the organization as a whole. Motivation takes forms like offering rewards, improving working conditions, or employee recognition. However, which approach should employers try? Team-based reward systems have been raised as an issue in work management areas. Many people prefer team-based reward systems to an individual approach. San Diego Business Journal, issued on Oct. 6, 1997, published an article titled â€Å"Team-Based Productivity Incentive System.† This article summarized the ideas that supported the team-based approach. The author, Bob Harrington, opposed the individual reward system. As he stated, individual reward systems create unnecessary competition and reduce cooperation between employees. It also reduces creativity because employees will only do what is necessary to get rewarded. Moreover, Harrington said team-based incentives influence individuals to work well together and cooperate with one another. No longer are employees and management measured purely against financial information. Instead, outstanding performance is based on a combination of items that measure the strategic objectives of the corporation. This paper will see if the team-based incentive systems are the best approach for business environments as Harrington discussed. Medical insurance and educational opportunities, among others are all common benefits in compensation programs for many manufacturers. Many people argued that these benefits attract and retain employees, but have little to do with work performance. Some also believe that if these benefits are spread out among workers in general, these kinds of work incentives will not guarantee good performance. Well Pay vs. Sick Pay is an example of how an incentive program reinforces wrong behavior and reduces productivity. Manufacturers with incentive systems that reward employees for achievements and growth can increase their competitiveness and profitability in today's global market. Yes, it is true that organizations need to have incentive systems to satisfy their work force. Team-based incentive systems such as gain sharing, profit sharing, etc., become increasingly popular in work environments. People now are required to work as a team, and altogether help each other to achieve an objective. Your work is my work, and your responsibility is mine. People will become more cohesive as working in a group or a team. Team-based incentives offer several advantages. However, I do not totally agree with Harrington that individual incentive systems do not have any good influence over workers' performance. Some people are extremely successful when they work on their own. People, who are raised in an individualistic culture, might not benefit from working in a group. So, individual incentive systems do play an important role in increasing a work force's productivity as long as the employers know how to use this reinforcement system properly. If organizations set a standard to measure individual achievement and reward that individual on what he (she) perform, then, the individual incentive system might work as well as the team-based one. Moreover, managers need to realize that team-based incentive systems might cause Social Loafing effect in the work force – the tendency for individuals to expend less effort when working collectively than when working individually (Robbins, 260). Motivations are necessary in a working environment to increase the productivity of the work force. Reward systems must create a win-win situation for employees and employers. Team-based incentive systems might work very well and are a preferred process for many organizations in today's work market; however, managers should adopt individual incentive systems in many cases, when employees are more skillful, efficient, and effective as working individually. The major purpose of the incentive system is to motivate and organize employees.

Synthesis of Certain Derivatives of Schiffbases

Microbiological Studies A definitive diagnosis of tuberculosis can only be made my culturing Mycobacterium tuberculosis organisms from a specimen taken from the patient (Most often sputum, but may also include pus, cerebero spinal fluid (CSF)), biopsied tissue, etc. Sputum smears and cultures should be done for acid-fast bacilli. The preferred method for the identification is fluorescence microscopy which is more sensitive than conventional Ziehl- Neelson staining denoted by Steingart et al. , 2006 6. If sputum is not produced, specimens can be obtained by gastric washings, an laryngeal swab, bronchoscopy with broncho alveolar lavage or fine needle aspiration of a collection. A comparative study found that inducing three sputum samples is more sensitive than three gastric washings. Many types of culture media are available. Traditionally Lowenstein –Jensen (LJ), Kirchner or Middle Brook media (7H9, 7H10, 7H11 and 7H12) are used for cultivating of Mycobacterial species. A culture of the acid-fast bacilli distinguishes the various forms of Mycobacteria. New automated systems that are faster include BACTEC 460 TB, BACTEC 9000 and the Mycobacterial growth Indicator tube (MGIT). The microscopic observation drug susceptibility assay (MODS) culture may be faster and more accurate method. Drugs Used In Tuberculosis in the current scenario Active tuberculosis will kill about two of every three people affected if left untreated. Treated tuberculosis if taken up early has a mortality rate of less than 5%. The standard short course treatment for tuberculosis comprises of Isoniazid, Rifampicin, Pyrazinamide and Ethambutol for two months, then Isoniazid and Rifampicin alone for a further four months. For latent tuberculosis, the standard treatment is six to nine months of Isoniazid alone. Drug regimens are abbreviated in a standardized manner. a). Streptomycin is STM or S b) Isoniazid is INH or H c) Rifampicin is RMP or R d) Ethambutol is EMB or E e) Pyrazinamide is PZA or Z. a)According to WHO norms, there are six classes of second line drugs that are used for the treatment of tuberculosis. A drug may be classified as second line instead of first line for one of two possible reasons; it may be less effective than the first line drugs or it may produce toxic side –effects. They are classified based on their chemical nucleus: Aminoglycosides – Amikacin and Kanamycin b)Polypeptides – Capreomycin c)Fluoroquinolones – Ciprofloxacin d)Thioamides – Ethionamide, Prothionamide and Cycloserine. e)Para-amino Salicylic acid. Tuberculosis has been treated by combination therapy over fifty years. Single drug treatment is ineffective and regimens that use only single drugs result in the rapid development of resistance and thus treatment results in failure. The rationale for using multiple drugs to treat tuberculosis is based on simple probability. The frequency of spontaneous mutations that confer resistance to an individual drug is well known: 1 in 10 7 for Ethambutol (EMB); 1 in 108 for streptomycin (STM) and Isoniazid (INH); 1 in 10 10 for Rifampicin (RMP). A patient with extensive pulmonary tuberculosis has approximately 10 12 bacteria in his body and therefore will probably be harbouring approximately 10 5 Ethambutol resistant bacteria, 10 4 Streptomycin resistant bacteria, 104 Isoniazid resistant bacteria and 102 Rifampicin resistant bacteria respectively. DOTS stands for ‘Directly Observed Therapy, Short – course’ and is a major plank in the WHO global tuberculosis eradication programme. The WHO advises that all tuberculosis patients should have atleast the first two months of their drug therapy should be observed with the aid of observer within that society. DOTS is used with intermittent dosing – Thrice weekly (Rifampicin, Isoniazid, Ethambutol and Pyrazinamide) or twice weekly. The relative incidence of major adverse effects has been carefully described . a)Isoniazid – Hepatitis, Neuropathy – 0. 49%. )Rifampicin – Skin rash, Thrombocytopenia and Hepatitis – 0. 43 % c)Pyrazinamide – Skin rash and Hepatitis – 1. 48 % d)Streptomycin – Vertigo – 0. 43 % Drug Resistant Tuberculosis (MDR and XDR – TB) Multi Drug Resistant Tuberculosis (MDR-TB) is defined as tuberculosis that is resistant at least to Isoniazid and Rifampicin isolates. In the year 200 6 â€Å"Extensively- Drug Resistant Tuberculosis† (XDR-TB) has emerged and defined as multi drug resistant tuberculosis that is resistant to quinolones and also to any one of kanamycin, capreomycin or amikacin. A 1997 survey of 35 countries found that 2% of the tuberculosis populations are infected by drug – resistant tuberculosis. The highest rates were in USSR, The Baltic states, Argentina, India and China. In 2006, MDR –TB in New York city has been increased to 20-30%. Annual risk of mortality rates increases by 10-15%. There is currently an epidemic of XDR-TB in South Africa. The outbreak was first reported as a cluster of 53 patients in a rural hospital in Kwazulu –Natal of whom 52 died . The treatment and prognosis of MDR-TB are much more akin to that of cancer than to that for infection. In these aspects, molecular manipulation is a productive source of new drugs. This research work pertains to the modification of Schiff bases on isoniazid to explore the new drugs with a desire to obtain highly potent, more specific and less toxic drugs. In the foregoing literature retrieval, it had been observed that the drug design can be performed by molecular manipulation and resulting in new productive drugs. The biological study of natural products with medicinally useful property and some of the chemical structure and its analogs had furnished to lead compounds, and its variation in the biological behavior. The pre-existing tuberculosis had made a challenging effect of medicinal chemists resulting in the extreme drug resistance. The performance of molecular manipulation still existed in a major line approach for the discovery of new drug analogues. To synthesize a derivative, an intermediate step has to be performed and to proceed for the further molecular manipulation. Combination of two or more active moieties in to one is a common procedure of manipulation and this can be possibly result in augmenting the activity, removal of untoward side effects and particularly to prevent development of resistance by the infectious microorganisms. Abundant literature support were available with regard to the study of Schiff bases as potent antibacterial, antifungal, antihypertensive, antiviral and anticancer perspectives. Schiff bases were the intermediate for the synthesis of azetidine -2 & 4- ones, thiazolidine -2 & 4- ones, triazoles & tetrazoles. It was interesting to observe that some analogues of Schiff bases were combined with other moieties like phenothiazines,hydrazines and some hydrazide derivatives of carboxylic acid resulting in a better performance in their respective biological activities. Hence, it was our interest to associate the Schiff bases with the primary drug isoniazid. Since Isoniazid is a well known antitubercular drug. As a vast number of reports were been available regarding the antitubercular perspectives of the isoniazid, there is still lacuna existing in the study of Schiff bases in the multi drug and extremely drug resistant M. tb strains. This study will full fill the properties of Schiff bases relevant to the prevailing drug resistant tuberculosis. Biological activities of Schiff bases Schiff bases are of interest and its important moiety which is associated with biological activity. Initially, most of the research program has been conducted to explore the antimicrobial perspectives of Schiff base derivatives. Based on the intermediate Schiff base various molecular manipulation were attempted to investigate and discover an effective antibacterials, antifungals & antiviral agents. In this preview of literature the various activities of Schiff bases pertaining to antibacterial perspectives has been studied. 1. Hearn et. al. , 2003 7 performed enzymatic acylation of the antitubercular isoniazid (INH) by N-acetyl transferases reduces therapeutic effectiveness of the drug. Since it dealt with the major metabolic pathway for INH in human beings, many of these derivatives were prepared and screened against Mycobacterium tuberculosis in the mice. They conclude the structural cogners of metabolites of INH may serve as significant leads in antitubercular drug discovery and in the exploration of the mode of action of INH. 2. Tarek Aboul – fadi et. al. , 2003 8 had synthesized N- alkyl derivative of INH and the Pharmacokinetic studies were been carried out in the bovine and sensitive strains of Mycobacterium tuberculosis. The pharmacokinetic study revealed that the rate and extent absorption of the tested derivatives. They show relative bioavailability of 183. 15 and 443. 25 respectively. 3. Sultana et. al. , 2007 9 studied the synthesis of hydrazones. The study afforded to the hitherto unreported 1-(4-chloro benzylidene) – hydrazinophthalazine, 1- nitrobenzylidene hydrazine phthalazine. , 3-(4-Chlorophenyl) –S-Triazolo (3,4-a) phthalazine. These structures were confirmed by spectroscopic techniques – IR, UV, H-NMR, EIMS, FD & HRMS. Anti hypertensive activity were been evaluated. 4. Koussi and Abdel rahman. , 2006 10 illustrated certain novel Schiff bases of 4- methyl-1,2,4 –triazole -3-mercaptoacetic acid hydrazide were synthesized and their chemical identities were elucidated by elemental analyses. IR, H-NMR,13- C-NMR and mass spectral data. The percentage of the geometrical isomers was elucidated using the 1-H NMR. The synthesized compounds were selected for screening at the tuberculosis antimicrobial acquisition and co-ordination facility against Mycobacterium tuberculosis H37RV strain in which they showed moderate activity at a concentration of 625 mg/mL. . Jiang et. al. , 2003 11 studied the series of chemically modified aryl- aldehyde Schiff bases has been synthesized and tested for their antioxidant activity and radiation protection. It was observed that disulfide –containing aryl –aldehyde schiff base exhibited potent free radical scavenging, antioxidation and radioprotective activities. 6. Pandeya et. al. ,1999 12 synthesized antib acterial, antifungal and anti human immunodeficiency virus activities of Schiff and Mannich bases derived from isatin derivatives and N – (4-(4’ chlorophenyl) thiazolyl thiosemi carbazide. Investigation of antimicrobial activity of compounds was done by agar dilution method. 7. Jayasekar et. al. , 1997 13 synthesized the Schiff bases of mesalazine and studied the anti inflammatory activity. The inhibition shows about 50-60% of the potency of the drug. In the present study, we had investigated certain Schiff base derivatives modified from isoniazid and it has screened for Extreme drug-resistant and Multidrug resistant tuberculosis strain procured from the patients suffering from tuberculosis. Bibilography: 1. Rothschild, B. , Martin, L. , Bercovier, L. G. , Gal, B. G. , Blatt, G. C. , Donoghue, H. , Spigelman, M and Brittain, D. Mycobacterium tuberculosis complex DNA from an extinct bison dated 17,000 years before the present. Clin. Infect. Dis. 30(3) : 305-311 ( 2001). 2. Pearce-Duvet, J. The origin of human pathogens evaluating the role of agriculture and domestic animals in the evolution of human disease. Biol. Rev. Camb. Philos. Soc. 31(3) : 369-382 (2006). 3. Koch, R. Die Aetiolgieder Tuberculosis. Berliner Klinsche Wochenschrift. 19 : 221-230 (1882). 4. Wells, A. Q. The Murine type of tubercle bacillus : Medical Research Council Special Report No. 259. HMSO, London (1946). 5. Mark Spigelman, 2008. Excavated Jericho Bones may help Israeli- Plaestinian – German team to combat tuberculosis. News release, Feb 29, (2008): 1-5. 6. Steingart,K. , Henry,M. , Pasval,G. , Avery,T. O and Lyall, W. H. Fluorescence versus conventional sputum smear microscopy for tuberculosis : a systematic review. Lancet. Infect. Dis. 6 : 570-571 (2006). 7. Michael J Hearn, Michael H Cynamon. Design and synthesis of antituberculars: preparation and evaluation against Mycobacterium tuberculosis of an isoniazid Schiff base. Journal of Anti Microb. Chemotherapy. 53(2):185-191 (2004). . Tarek Aboul-Fadl, Faragany Abdel-Hamid Mohammed, Ehsan Abdel-Saboor Hassan. Synthesis, antitubercular activity and pharmacokinetic studies of some Schiff bases derived from 1-alkylisatin and isonicotinic acid hydrazide (INH). ARCHIVES OF PHARMACAL RESEARCH , 26(10):778-784 ( 2003 ). 9. Sultana-N; Sarfaraz-TB; Nelofar-A; Hussain-SA. Potential antibacterial agents: Part VI â₠¬â€œ Synthesis and structure elucidation of schiff bases derived from hydralazine. Pak-J-Sci-Ind-Resch (Pakistan-Journal-of-Scientific-and-Industrial-Research); 50(3); 169-172 (2007). 10. El-Koussi-NA; Abdel-Rahman-HM . Novel 1,2,4-triazole-3-mercaptoacetic acid derivatives as potential antimycobacterial and antimicrobial agents. Bull-Pharm-Sci-Assiut-Univ (Bulletin-of-Pharmaceutical-Sciences); 29(Part 1); 127-136 (2006). 11. Jiang-JJ; Chang-TC; Hsu-WF; Hwang-JM; Hsu-LY. Synthesis and biological activity of sulfur-containing aryl-aldehyde Schiff bases. Chem-Pharm-Bull (Chemical-and-Pharmaceutical-Bulletin); 51(11); 1307-1310 (2003). 12. Pandeya-SN; Sriram-D; Nath-G; De-Clercq-E. Synthesis, antibacterial, antifungal and anti HIV activity of Schiff and Mannich bases of isatin with N-(6-chlorobenzothiazol-2-yl) thiosemicarbazide. Indian-J-Pharm-Sci (Indian-Journal-of-Pharmaceutical-Sciences); 61(6); 358-361 (1999). 13. Jayasekhar-P; Rao-SB; Santhakumari-G. Synthesis and anti-inflammatory activity of Schiff bases of mesalazine. Indian-J-Pharm-Sci (Indian-Journal-of-Pharmaceutical-Sciences); 59(1); 8-12 (1997). 14. Mcomia ; Protective group in Organic chemistry. P-66. 15. Trivedi,P. , Undavia,N. K. ,Dave, A. M. , Bhatt,K. N and Desai ,N. C. Indian Journal of Chem . , Vol 32B(7) : 760-765 ( 1993). 16. Divakar, C. M and Nair, G. R. N. Antiulcer, antibacterial and spermicidal activities of Salanin. Indian Drugs. 38(2): 629-932 (2001).

Food in a Pill Essay

Imagine you’re at work. It’s another busy day and your schedule is packed with meetings. It appears that you’ll have to skip lunch yet again, since you just don’t have the time. Then you remember that you have a hamburger in your pocket, and you pull out a few pills with all the ingredients of a hamburger packed into them. It’s food in a pill and it can change the way that people eat forever. With food in a pill, people can eat all kinds of foods in seconds. It completely fills them up just like a regular meal and it saves valuable time. It uses new technology that packs flavor and all the nutrients and vitamins the food originally has into a pill. Then when a person swallows the pill, it releases all these things into the body, making them feel like they can’t eat another bite. This invention will revolutionize food and people’s lives by making meal time a quick, easy way to meet a person’s daily nutritional needs. With food in a pill, there is no need to have to spend the time preparing your food every day. It’s quick and easy, unlike cooking and buying all the ingredients for a recipe. Whenever you are hungry, you just need to swallow one pill and your hunger is satisfied. A trip to the grocery store is easy and less expensive with only a few pills on your list. No need to waste gas and drive to a restaurant to get a good pizza, you can just grab a pill from the grocery store and eat on the way home. The production of these pills will create jobs and the need for people to create other inventions, such as devices to mix pills. Food in a pill is inexpensive and can save people money, because all you need to do is buy a few pills, not a whole entire meal. Family gatherings can be easier, when instead of rushing around trying to prepare all three courses, you can relax and meet with relatives while only having to hand out pills for dinner. Food in a pill will change the world and create innovation that will increase the experience of daily life.